ADCs: New Ways to Achieve Precision Conjugation and Scalable Purification

Although highly successful, the complexities involved in controlling conjugation reactions and purifying the final drug mean it remains especially challenging to manufacture and develop processes for ADC compounds. In this webinar, sponsored by Cytiva, our main speakers and panelists will highlight chemical methods to precisely control stoichiometry and mixing during conjugation, dramatically reducing HMW impurities at the source, simplifying your entire workflow. We will also learn more about scalable purification processes for ADCs, tackling key challenges like free drug removal through integrating protein A capture, cation exchange chromatography, and TFF to boost the robustness of your ADC development and manufacturing processes. 

Key Highlights:

• Presentation of a flow chemistry method to control conjugation stoichiometry and limit HMW impurities
• Insight into an integrated large-scale purification process for antibodies and ADCs, including strategies to overcome the critical challenge of free drug removal.
• Expert panel discussion discussing most pressing issues in ADC process development & manufacturing today

Why Attend:

• Get practical tips to gain precise control over the conjugation reaction, reducing impurities at the source and significantly simplifying your downstream process.
• Learn about scalable purification strategies using chromatography and TFF, ultimately saving you time and resources in developing your processes.
• Opportunity to put your questions to our panel of experts and speakers

Join us for an informative session that will help understand how to achieve superior conjugate quality, reduce purification burdens, and accelerate your ability to develop better manufacturing processes. Register now to secure your spot!