TPD: A Promising Future

Growth of TPD

• The investment in TPD has led to accelerated growth in the field. Since the launch of TPD in March, the number of assets has grown across all therapeutic classes by 50%. This growth is led by bivalent degraders, which have grown by 56%.
• Clinical activity has also increased since March 2021, with the number of clinical bivalent degraders increasing from 4 assets, to 10.

Degradation Pathways of the Future

Many developers are already evaluating alternative degradation pathways, such as autophagy and lysosomal degradation, with new therapeutic classes including ATACs, CHAPTACs and ATTECs appearing since March.

The field of TPD has seen incredible developments since March. The 54% growth in bivalent degrader assets is matched by a significant number of assets entering the clinic since March.

Many companies and universities are seeing the opportunities that TPD brings and are focusing their research efforts to develop degraders, whether using traditional methods or their novel proprietary technologies.

Due to the large scale investments taking place in TPD, the field is already seeing a diversification of its degradation pathways, with many assets focused on autophagy and lysosomal degradation.